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Hypocretin as circadian alertness signal

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Zeitzer JM (2021) The neurobiological underpinning of the circadian wake signal. Biochemical Pharmacology 191: 114386.

Zeitzer JM, Joyce DS, McBean A, Quevedo YL, Hernandez B, Holty J-E (2020) Effect of suvorexant vs placebo on total daytime sleep hours in shift workers: a randomized clinical trial. JAMA Open 3(6): e206614. PMCID: PMC7267849

Friedman L, Zeitzer JM, Lin L, Hoff D, Mignot E, Peskind ER, Yesavage JA (2007) In Alzheimer disease, increased wake fragmentation found in those with lower hypocretin-1. Neurology 68: 793-794.

Zeitzer JM, Buckmaster CL, Lyons DM, Mignot E (2007) Increasing length of wakefulness on hypocretin-1 in the wake-consolidating squirrel monkey. American Journal of Physiology 293: R1736-R1742.

Zeitzer JM, Buckmaster CL, Lyons DM, Mignot E (2004) Locomotor-dependent and -independent components to hypocretin-1 (orexin A) regulation in a sleep/wake consolidating monkey. Journal of Physiology (London) 57: 1045-1053. PMCID: PMC1665142

Zhang S, Zeitzer JM, Yoshida Y, Wisor JP, Nishino S, Edgar DM, Mignot E (2004) Suprachiasmatic nucleus lesions eliminate daily rhythm of hypocretin-1 release. Sleep 27: 619-627.

Salomon RM, Ripley B, Kennedy JS, Johnson B, Schmidt D, Zeitzer JM, Nishino S, Mignot E (2003) Diurnal variation of CSF hypocretin-1 (orexin-A) levels in control and depressed subjects. Biological Psychiatry 54: 96-104.

Zeitzer JM, Buckmaster CL, Parker KJ, Hauk CM, Lyons DM, Mignot E (2003) Circadian and homeostatic regulation of hypocretin in a primate model: implications for consolidation of wake. Journal of Neuroscience 23: 3555-3560.