Recent and featured publications

For a full listing of articles, see: https://www.ncbi.nlm.nih.gov/myncbi/jamie.zeitzer.2/bibliography/public/

Human centric lighting (basic and clinical studies)

Lok R, Joyce DS, Zeitzer JM (2022) Impact of daytime spectral tuning on daytime cognitive function. Journal of Photochemistry and Photobiology, B: Biology 230:112439.

Joyce DS, Houser KW, Peirson SN, Zeitzer JM, Zele AJ (2022) Melanopsin vision: sensation and perception through intrinsically photosensitive retinal ganglion cells. Elements in Perception. Cambridge: Cambridge University Press, pp. 1-67.

Houser KW, Boyce PR, Zeitzer JM, Herf M (2021) Human-centric lighting: myth, magic, or metaphor? Lighting Research and Technology 53: 97-118.

Gabel V, Miglis M, Zeitzer JM (2020) Effect of artificial dawn light on cardiovascular function, alertness, and balance in older adults. Sleep 43(10):zsaa082.

Zeitzer JM (2018) When is a proxy not a proxy? The foibles of non-image forming light. Journal of Physiology 596(11): 2029-2030. [Letter] PMCID: PMC5983144

Zeitzer JM, Najjar RP, Wang C-A, Kass M (2018) Impact of blue-depleted white light on pupil dynamics, melatonin suppression and subjective alertness following real-world light exposure. Sleep Science and Practice 2: 1.

McBean AL, Najjar RP, Schuchard R, Hall CD, Zeitzer JM (2016) Standing balance and temporal and spatial aspects of gait are impaired upon nocturnal awakening in healthy older adults. Journal of Clinical Sleep Medicine 12: 1477-1486. PMCID: PMC5078702

Zeitzer JM (2015) Real life trumps laboratory in matters of public health. Proceedings of the National Academy of Sciences USA 112:E1513 [Letter] PMCID: PMC4386401

Friedman L, Spira AP, Hernandez B, Mather C, Sheikh J, Ancoli-Israel S, Yesavage JA, Zeitzer JM (2012) Brief morning light treatment for sleep/wake disturbances in older memory-impaired individuals and their caregivers. Sleep Medicine 13:546-549. PMCID: PMC3337852

Zeitzer JM, Friedman L, Yesavage JA (2011) Effectiveness of evening phototherapy for insomnia is reduced by bright daytime light exposure. Sleep Medicine 12: 805-807. PMCID: PMC3176957

Friedman L, Zeitzer JM, Kushida C, Zhdanova I, Noda A, Lee T, Schneider B, Guilleminault C, Sheikh J, Yesavage JA (2009) Scheduled bright light for treatment of insomnia in older adults. Journal of the American Geriatrics Society 57: 441-452. PMCID: PMC2743069

Duffy JF, Zeitzer JM, Czeisler CA (2007) Decreased sensitivity to phase-delaying effects of moderate light intensity in older subjects. Neurobiology of Aging 28: 799-807. PMCID: PMC1855248

Zeitzer JM, Khalsa SBS, Duffy JF, Boivin DB, Shanahan TL, Kronauer RE, Dijk D-J, Czeisler CA (2005) Temporal dynamics of late-night photic stimulation of the human circadian timing system. American Journal of Physiology 289: R839-R844.

Zeitzer JM, Dijk D-J, Kronauer RE, Brown EN, Czeisler CA (2000) Sensitivity of the human circadian pacemaker to nocturnal light: melatonin phase resetting and suppression. Journal of Physiology (London) 526: 695-702. PMCID: PMC2270041

Cajochen C, Zeitzer JM, Czeisler CA, Dijk D-J (2000) Dose-response relationship for light intensity and ocular and electroencephalographic correlates of alertness in humans. Behavioral Brain Research 115: 75-83.

Zeitzer JM, Kronauer RE, Czeisler CA (1997) Photopic transduction implicated in human circadian entrainment. Neuroscience Letters 232: 135-138.

Light flash therapy (basic studies)

Lok R, Duran M, Zeitzer JM (2023) Moving time zones in a flash with light therapy during sleep. Scientific Reports 13:14458. PMCID: PMC10475014

Joyce D, Spitschan M, Zeitzer JM (2022) Optimizing light flash sequence duration to shift human circadian phase. Biology 11(12):1807. PMCID: PMC9775356

Joyce DS, Spitschan M, Zeitzer JM (2022) Duration invariance and intensity dependence of the human circadian system phase shifting response to brief light flashes. Proceedings B 289: 20211943. PMCID: PMC8905166

Kaladchibachi S, Negelspach D, Zeitzer JM, Fernandez F (2022) Investigation of the aging clock’s intermittent-light responses uncovers selective deficits to green millisecond flashes. Journal of Photochemistry and Photobiology B: Biology 228:112389.

Kaladchibachi S, Negelspach DC, Zeitzer JM, Fernandez F (2019) Optimization of circadian responses with shorter and shorter millisecond flashes. Biology Letters 15: 20190371. PMCID: PMC6731482

Najjar RP, Zeitzer JM (2016) Temporal integration of light flashes by the human circadian system. Journal of Clinical Investigation 126: 938-947. PMCID: PMC4767340

Zeitzer JM, Fisicaro RA, Ruby NF, Heller HC (2014) Millisecond flashes of light phase delay the human circadian clock during sleep. Journal of Biological Rhythms 29:370-376. PMCID: PMC5056587

Zeitzer JM, Ruby NF, Fisicaro RA, Heller HC (2011) Response of the human circadian system to millisecond flashes of light. PLoSOne 6: e22078. PMCID: PMC3132781

Adolescents (a collaboration with Ya-Ting Yang)

Yang Y-T, Chang H-Y, Hsu C-Y, Lin C-Y, Zeitzer JM (2022) Chinese translation and validation of the Adolescent Sleep Wake Scale. Sleep Science and Practice 6:9.

Yang Y-T, Chang H-Y, Hsu C-Y, Zeitzer JM (2021) Translation and validation of a Chinese version of the Cleveland Adolescent Sleepiness Questionnaire. Nature and Science of Sleep 13:695-702. PMCID: PMC8179797

Yang Y-T, Chang H-Y, Hsu C-Y, Lin C-Y, Zeitzer JM (2020) Chinese translation and validation of the Child and Adolescent Sleep Checklist for Parents. Sleep Medicine Research 11(2):102-107.

Yang Y-T, Kaplan KA, Zeitzer JM (2020) A comparison of sleep, depressive symptoms, and parental perceptions between U.S. and Taiwan adolescents with self-reported sleep problems. Sleep Advances 1(1): zpaa004. PMCID: PMC7731573

Kaplan KA, Mashash M, Williams R, Batchelder H, Star-Glass L, Zeitzer JM (2019) Effect of light flashes vs sham therapy during sleep with adjunct cognitive behavioral therapy on sleep quality among adolescents: a randomized clinical trial. JAMA Network Open 2: e1911944. PMCID: PMC6763980

Nathan N, Zeitzer JM (2013) A retrospective survey study of mobile phone use and its effects on daytime sleepiness in California high school students. BMC Public Health 13:840. PMCID: PMC3847218

Biological underpinnings of sleep phenomena

Lok R, Chawra D, Hon F, Ha M, Kaplan KA, Zeitzer JM (2022) Physiologic underpinnings of subjective sleep quality in middle-aged and older adults: the importance of N2 and wakefulness. Biological Psychology 170:108290. PMCID: PMC9038649

Lok R, Zeitzer JM (2021) Physiological correlates of the Epworth sleepiness scale reveal different dimensions of daytime sleepiness. Sleep Adv 2(1): zpab008. PMCID: PMC8266524

Faerman A, Kaplan KA, Zeitzer JM (2020) Poor association between actigraphy, heart rate measures and subjective sleep quality in healthy older men. Sleep Medicine 73:154-161.

Boussard J, Kochenderfer MJ, Zeitzer JM (2019) Predicting subjective sleep quality using recurrent neural networks. 2019 IEEE Signal Processing in Medicine and Biology Symposium, L01.06.

Kaplan KA, Hardas P, Redline S, Zeitzer JM (2017) Correlates of sleep quality in midlife and beyond: a machine learning analysis. Sleep Medicine 34:162-167. PMCD: PMC5456454.

Kaplan KA, Hirshman J, Hernandez B, Stefanick M, Hoffman AR, Redline S, Ancoli-Israel S, Stone K, Friedman L, Zeitzer JM (2017) When a gold standard isn't so golden: lack of prediction of subjective sleep quality from sleep polysomnography. Biological Psychology 123: 37-46. PMCID: PMC5292065

Hypocretin as circadian alertness signal

Zeitzer JM (2021) The neurobiological underpinning of the circadian wake signal. Biochemical Pharmacology 191: 114386.

Zeitzer JM, Joyce DS, McBean A, Quevedo YL, Hernandez B, Holty J-E (2020) Effect of suvorexant vs placebo on total daytime sleep hours in shift workers: a randomized clinical trial. JAMA Open 3(6): e206614. PMCID: PMC7267849

Zeitzer JM, Buckmaster CL, Landolt H-P, Lyons DM, Mignot E (2009) Modafinil and gamma-hydroxybutyrate have sleep state-specific pharmacological actions on hypocretin-1 physiology in a primate model of human sleep. Behavioural Pharmacology 20: 643-652. PMCID: PMC2939929

Friedman L, Zeitzer JM, Lin L, Hoff D, Mignot E, Peskind ER, Yesavage JA (2007) In Alzheimer disease, increased wake fragmentation found in those with lower hypocretin-1. Neurology 68: 793-794.

Zeitzer JM, Buckmaster CL, Lyons DM, Mignot E (2007) Increasing length of wakefulness on hypocretin-1 in the wake-consolidating squirrel monkey. American Journal of Physiology 293: R1736-R1742.

Zeitzer JM, Nishino S, Mignot E (2006) The neurobiology of hypocretins (orexins), narcolepsy and therapeutic interventions. Trends in Pharmacological Sciences 27:368-374.

Zeitzer JM, Buckmaster CL, Lyons DM, Mignot E (2004) Locomotor-dependent and -independent components to hypocretin-1 (orexin A) regulation in a sleep/wake consolidating monkey. Journal of Physiology (London) 57: 1045-1053. PMCID: PMC1665142

Zhang S, Zeitzer JM, Yoshida Y, Wisor JP, Nishino S, Edgar DM, Mignot E (2004) Suprachiasmatic nucleus lesions eliminate daily rhythm of hypocretin-1 release. Sleep 27: 619-627.

Salomon RM, Ripley B, Kennedy JS, Johnson B, Schmidt D, Zeitzer JM, Nishino S, Mignot E (2003) Diurnal variation of CSF hypocretin-1 (orexin-A) levels in control and depressed subjects. Biological Psychiatry 54: 96-104.

Zeitzer JM, Buckmaster CL, Parker KJ, Hauk CM, Lyons DM, Mignot E (2003) Circadian and homeostatic regulation of hypocretin in a primate model: implications for consolidation of wake. Journal of Neuroscience 23: 3555-3560.

Actigraphy as a biomarker

Xiao Q, Sampson JN, LaCroix AZ, Shadyab AH, Zeitzer JM, Ancoli-Israel S, Yaffe K, Stone K, Osteoporotic Fractures in Men (MrOS) Study Group (2021) Nonparametric parameters of 24-hour rest-activity rhythms and long-term cognitive decline and incident cognitive impairment in older men. Journal of Gerontology: Biological Sciences 77:250-258.

Xiao Q, Lu J, Zeitzer JM, Matthews CE, Saint-Maurice PF, Bauer C (2022) Rest-activity profiles among U.S. adults in a nationally representative sample: a functional principal component analysis. International Journal of Behavioral Nutrition and Physical Activity 19: 32.

Miner B, Stone KL, Zeitzer JM, Han L, Doyle M, Blackwell T, Gill TM, Redeker NS, Hajduk A, Yaggi HK (2021) Self-reported and actigraphic short sleep duration in persons with advanced age. Journal of Clinical Sleep Medicine 18: 403-413.

Posner AB, Tranah GJ, Blackwell T, Yaffe K, Ancoli-Israel S, Redline S, Leng Y, Zeitzer JM, Chen DM, Webber KR, Stone KL (2021) Predicting incident dementia and mild cognitive impairment in older women with nonparametric analysis of circadian activity rhythms in the Study of Osteoporotic Fractures. Sleep 44: zsab119.

Zeitzer JM, Blackwell T, Hoffman AR, Ancoli-Israel S, Stone K, MrOS (2018) Daily patterns of accelerometer activity predict changes in sleep, cognition, and mortality in older men. Journal of Gerontology A Biological Science and Medical Science 73: 682-687. PMCID: PMC5905637

Zeitzer JM, David R, Friedman L, Mulin E, Garcia R, Wang J, Yesavage JA, Robert PH, Shannon W (2013) Phenotyping apathy in individuals with Alzheimer’s using functional principal component analysis. American Journal of Geriatric Psychiatry 21:391-397. PMCID: PMC3603283.

Sleep methodology

Brink-Kjaer A, Winer J, Zeitzer JM, Sorensen HBD, Jennum P, Mignot E, During E (2023) Fully automated detection of isolated rapid-eye-movement sleep behavior disorder using actigraphy. 45th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, in press.

Olsen M, Zeitzer JM, Richardson RN, Davidenko P, Jennum PJ, Sørensen HBD, Mignot EJ (2023) A flexible deep learning architecture for temporal sleep stage classification using accelerometry and photoplethysmography. IEEE Transactions on Biomedical Engineering 70(1):228-237.

Weed L, Lok R, Chawra D, Zeitzer JM (2022) The impact of missing data and imputation methods on the analysis of 24-hour activity patterns. Clocks & Sleep 4:497-507. PMCID: PMC9590093

Lok R, Zeitzer JM (2020) A temporal threshold for distinguishing off-wrist from inactivity periods: a retrospective actigraphy analysis. Clocks & Sleep 2(4):466-472. PMCID: PMC7712166

Cheung J, Leary E, Lu H, Zeitzer J, Mignot E (2020) PSG validation of minute-to-minute scoring for sleep and wake periods in a consumer wearable device. PLoSOne 15(9):e0238464. PMCID: PMC7498244

Gabel V, Kass M, Joyce DS, Spitschan M, Zeitzer JM (2019) Auditory psychomotor vigilance testing in older and young adults – a revised threshold setting procedure. Sleep and Breathing 23: 1021-1025.

Cheung J, Zeitzer JM, Lu H, Mignot E (2018) Validation of minute-to-minute scoring for sleep and wake periods in a consumer wearable device compared to an actigraphy device. Sleep Science and Practice 2:11.

Althoff T, Horvitz E, White RW, Zeitzer J (2017) Harnessing the web for population-scale physiologic sensing: a case study of sleep and performance. Proceedings of the 26th International Conference on World Wide Web: 113-122.

Breast cancer (a collaboration with David Spiegel)

Nouriani B, Zeitzer JM, Palesh OG, Koopman C, Aldridge-Gerry A, Neri E, Medina JL, Spiegel D (2022) Assessment of sleep and circadian rhythms of endocrine and immune function among women with advanced breast cancer. Research Methods in Medicine and Health Sciences 4(2):71-85.

Allende S, Medina J, Spiegel D, Zeitzer JM (2020) Evening salivary cortisol as a single stress marker in women with metastatic breast cancer. Psychoneuroendocrinology 115: 104648.

Zeitzer JM, Nouriani B, Rissling M, Sledge G, Kaplan KA, Aasly L, Palesh O, Jo B, Neri E, Dhabhar F, Spiegel D (2016) Aberrant nocturnal cortisol and disease progression in women with breast cancer. Breast Cancer Research and Treatment 158:43-50. PMCID: PMC4938753

Zeitzer JM, Nouriani B, Neri E, Spiegel D (2014) Correspondence of plasma and salivary cortisol patterns in women with breast cancer. Neuroendocrinology 100:153-161. PMCID: PMC4304942

Palesh O, Gerry-Aldridge A, Zeitzer JM, Koopman C, Neri E, Giese-Davis J, Jo B, Kraemer HC, Nouriani B, Spiegel D (2014) Actigraphy-measured sleep disruption as a predictor of survival among women with advanced breast cancer. Sleep 37:837-842.PMCID: PMC3985107.

Hahm B-J, Jo B, Dhabhar FS, Palesh O, Aldridge-Gerry A, Bajestan SN, Neri E, Nouriani B, Spiegel D, Zeitzer JM (2014) Circadian misalignment of preferred vs. habitual bedtime and progression of breast cancer. Chronobiology International 31:214-221. PMCID: PMC5063046

Traumatic brain injury (a collaboration with Risa Nakase-Richardson)

Zeitzer JM, Hon F, Whyte J, Monden KR, Bogner J, Dahdah M, Wittine L, Bell KR, Nakase-Richardson R (2020) Coherence between sleep detection by actigraphy and polysomnography in a multi-center, in-patient cohort of individuals with traumatic brain injury. PMR 12(12):1205-1213.

Nakase-Richardson R, Schwartz DJ, Drasher-Phillips L, Ketchum JM, Calero K, Dahdah MN, Monden KR, Bell K, Magalang U, Hoffman J, Whyte J, Bogner J, Zeitzer JM (2019) Comparative effectiveness of sleep apnea screening instruments during inpatient rehabilitation following moderate to severe TBI. Archives of Physical Medicine and Rehabilitation 101(2): 283-296.

Towns SJ, Zeitzer JM, Kamper J, Holcomb E, Silva MA, Schwartz DJ, Nakase-Richardson R (2016) Implementation of actigraphy in acute traumatic brain injury neurorehabilitation admissions: a Veterans Administration TBI Model Systems feasibility study. PM&R 8: 1046-1054.

Kamper JE, Garofano J, Schwartz D, Silva MA, Zeitzer JM, Modarres M, Barnett S, Thomas BA, Nakase-Richardson R (2016) The concordance of actigraphy with polysomnography in TBI neurorehabilitation admissions. Journal of Head Trauma Rehabilitation 31:117-125.

Bipolar disorder (a collaboration with Robert Gonzalez and Anda Gershon)

Gonzalez R, Dwivedi A, Zeitzer J, Suppes T, Tohen M, Alvarado A, Forero A (2022) Chronobiologically-based sub-groups in bipolar I disorder: a latent profile analysis. Journal of Affective Disorders 299: 691-697.

Gonzalez R, Suppes T, Zeitzer J, McClung C, Tamminga C, Tohen M, Forero A, Dwivedi A, Alvarado A (2018) The association between mood state and chronobiological characteristics in bipolar I disorder: a naturalistic, variable cluster analysis-based study. International Journal of Bipolar Disorders 6: 5. PMCID: PMC6161964

Gershon A, Ram N, Johnson SL, Harvey AG, Zeitzer JM (2016) Daily actigraphy profiles distinguish depressive and interepisode states in bipolar disorder. Clinical Psychological Science 4:641-650. PMCID: PMC5022043

Spinal cord injury

Zeitzer JM, Ku B, Ota D, Kiratli BJ (2014) Randomized controlled trial of pharmacologic replacement of melatonin for sleep disruption in individuals with tetraplegia. Journal of Spinal Cord Medicine 37:46-53. PMCID: PMC4066551.

Scheer FAJL, Zeitzer JM, Ayas NT, Brown R, Czeisler CA, Shea SA (2006) Reduced sleep efficiency in cervical spinal cord injury; association with abolished nighttime melatonin secretion. Spinal Cord 44: 78-81. PMCID: PMC2882209

Zeitzer JM, Ayas NT, Wu AD, Czeisler CA, Brown R (2005) Bilateral oculosympathetic paresis is associated with a loss of nocturnal melatonin secretion in spinal cord injury patients. Journal of Spinal Cord Medicine 28: 55-59.

Zeitzer JM, Ayas N, Shea SA, Brown R, Czeisler CA (2000) Absence of detectable melatonin and preservation of cortisol and thyrotropin rhythms in tetraplegia. Journal of Clinical Endocrinology and Metabolism 85: 2189-2196.

Basic human circadian

Burgess HJ, Zeitzer JM (2022) Melatonin. In: Principles and Practice of Sleep Medicine. 7th edition. Ch. 51, M Kryger, T Roth, CA Goldstein, WC Dement, eds. Elsevier: Philadelphia PA, pp. 506-509.

Duffy JF, Zeitzer JM, Rimmer DW, Klerman EB, Dijk D-J, Czeisler CA (2002) Peak of circadian melatonin rhythm occurs later within the sleep of older subjects. American Journal of Physiology 282:E297-E303.

Klerman EB, Zeitzer JM, Duffy JF, Khalsa SB, Czeisler CA (2001) Absence of an increase in the duration of the circadian melatonin secretory episode in totally blind human subjects. Journal of Clinical Endocrinology and Metabolism 86:3166-3170.

Zeitzer JM, Daniels JE, Duffy JF, Klerman EB, Shanahan TL, Dijk D-J, Czeisler CA (1999) Plasma melatonin concentration: does it decline with age? American Journal of Medicine 107: 432-436.

Randomness!

Blum DJ, Hernandez B, Zeitzer JM (2023) Early time-restricted eating advances sleep in late sleepers: a pilot randomized controlled trial. Journal of Clinical Sleep Medicine, in press.

Solomon N, Zeitzer JM (2019) The impact of chronotype on prosocial behavior. PLoSOne 14(4):e0216309. PMCID: PMC6490933

Pardi DJ, Buman MP, Black J, Lammers GJ, Zeitzer JM (2017) Eating decisions based on alertness levels after a single night of sleep manipulation. Sleep 40: zsw039.

Zeitzer JM, Bliwise DL, Hernandez B, Friedman L, Yesavage JA (2013) Nocturia compounds nocturnal wakefulness in older individuals with insomnia. Journal of Clinical Sleep Medicine 9:259-262. PMCID: PMC3578689

Nova P, Hernandez B, Ptolemy A, Zeitzer JM (2012) Modeling caffeine concentrations with the Stanford Caffeine Questionnaire: preliminary evidence for an interaction of chronotype on the effects of caffeine on sleep. Sleep Medicine 13: 362-367.

Zeitzer JM, Fisicaro RA, Grove ME, Mignot E, Yesavage JA, Friedman L (2011) Faster REM sleep EEG and worse sleep satisfaction in older insomniacs with HLA DQB1*0602. Psychiatry Research 187: 397-400. PMCID: PMC3079052

Zeitzer JM, Morales-Villagran A, Maidment NT, Behnke EJ, Ackerson LC, Lopez-Rodriguez F, Fried I, Engel Jr J, Wilson CL (2006) Extracellular adenosine in the human brain during sleep and sleep deprivation: an in vivo microdialysis study. Sleep 29: 455-461.

Zeitzer JM, Maidment NT, Behnke EJ, Ackerson L, Fried I, Engel Jr J, Wilson CL (2002) Ultradian sleep-cycle variation of serotonin in the human lateral ventricle. Neurology 59:1272-1274.